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Longevity Nation Conference – 26-27 March 2023 – Bar-Ilan University, Israel

January 17, 2023Advocacy, Hebrew עברית, Scienceilia2014

The conference: Longevity Nation –

Enhancing research development and education for healthy longevity

March 26-27, 2023

Bar Ilan University, Nanotechnology Bldg 206, Ramat Gan, Israel

This conference will explore the interdisciplinary interrelations of science, technology and society in addressing the challenges of population aging. By bringing together leading voices in the longevity space and public figures, the Longevity Nation conference will help advance ethical scientific and technological solutions for healthy longevity for the benefit of the entire society. Building on Israel’s strengths in this area, this conference will help enhance the supportive longevity ecosystem in Israel, boost the prominence of the field in Israel and strengthen Israel’s international standing and cooperation in the Longevity Field. It will help build up longevity R&D and Education support programs, for stakeholders in Israel and international collaborators.

http://www.longevitynation.org/

The registration is at the link below (the attendance is free, but registration is required). The page also includes information for possible support for Vetek (Seniority) Association – the Movement for Longevity and Quality of Life, Israel, the chief organizer of this conference.

http://www.longevitynation.org/register-free-and-donate/

Looking forward to seeing you and jointly promoting research, development and education for healthy longevity!

Ilia Stambler, PhD

Chairman of the organizing committee

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הכנס – LONGEVITY NATION – הגברת מחקר, פיתוח וחינוך לקידום אריכות חיים בריאים

יתקיים ב-26-27 במרץ, 2023

באוניברסיטת בר-אילן, בניין הננוטכנולוגיה 206, רמת גן

הכנס עוסק ביחסי הגומלין הבין-תחומיים של מדע, טכנולוגיה וחברה כדי לטפל באתגרים של הזדקנות האוכלוסייה האנושית. על ידי גיבוש קהילה המפגישה אנשי ציבור עם האנשים המובילים בתחום אריכות החיים, כנס LONGEVITY NATION עוזר לקדם את הפתרונות האתיים, המדעיים והטכנולוגיים לאריכות ימים בבריאות לטובת החברה בכללותה. הכנס בונה על יתרונותיה וחוזקותיה המשמעותיים של מדינת ישראל בתחומים אלה, ומטרתו לשפר את האקוסיסטמה התומכת באריכות חיים בריאים בישראל, להגביר את הנראות והבולטות של התחום בישראל ולחזק את מעמדה ושיתוף הפעולה הבינלאומי של ישראל בתחום אריכות החיים הבריאים. הכנס יסייע לבנות תוכניות תמיכה למו”פ וחינוך לקידום אריכות חיים בריאים עבור בעלי עניין בישראל ויצירת שיתוף פעולה עם גורמים בינלאומיים.

http://www.longevitynation.org/

הקישור להרשמה לכנס להלן (הכניסה חופשית אך ההרשמה נדרשת). הדף גם כולל נתונים לתמיכה בעמותת ותק – התנועה לאיכות ואריכות חיים (ע”ר), המארגנת הראשית של הכנס.

http://www.longevitynation.org/register-free-and-donate/

מצפים לראותכם ולשיתוף פעולה בקידום מחקר, פיתוח וחינוך לאריכות חיים בריאים.

ד”ר איליה סטמבלר

יו”ר הועד המארגן

اسرار اطالة العمر

October 26, 2022Arabic العربيةilia2014

ان مساله اطاله العمر هو من المسائل الذي تحتاج لوقفه ودراسة وانه لمن الممكن اطاله العمر ان لم يتعرض الشخص لحادث او عدوى، وانه لمن المؤكد ان المؤكد من نهج الطب القائم حالياً يحتاج لإعادة دراسة و طرح لأنه مع ازدياد وسائل الرفاهية والرخاء يحتاج الانسان لمزيد من وسائل العناية والصحة فلم تكن العربات القديمة تحتوي وسائل الرفاهية كما هو الان وقس على ذلك ، إن المعمرين الذين تسمع عنهم في ما يسمى المناطق الزرقاء blue zone نشأت على عادات وتقاليد غذائية اهلتهم لان تطول اعمارهم ، فالمشي على الحبال مهاره قد تكتسب من الصغر وتحتاج لمجهود اكبر ان تتعلمها عند الكبر وهنا نجد ان أخصائية التغذية واللياقة البدنية و مؤخراً خبراء إطالة العمر كل يدلو دلوه ، حتى انه المنظومة الطبية او الطب الحديث اصبح بحيره هل يتعامل مع علاج الشيخوخة واطاله العمر على انه امر واجب او الاكتفاء بعلاج الامراض والأعراض ، فالفرد لا يستطيع دخول المستشفى ومقابله الطبيب ويطلب منه علاج الشيخوخة او شيء لاطاله العمر ولكن ان كان في بلد ذا رفاهيه او رخاء فقد يستطيع التوجه لمقدمه هذه الخدمة ، وليس للشيخوخة اعتراف كمرض من منظمه الصحة العالمية فلا رمز مباشر لها ولكن هناك رموز غير مباشره في التصنيف الدولي للأمراض

ICD

International classification of disease

مثل رمز

R54:senility

XT9T: age related disease

وقد يكون الحديث عن اطاله العمر به شيء من الطيش او عدم الواقعية خاصه في البلاد ضعيفة الاقتصاد وقليله الابتكار ، كذلك يجد البعض انه من الأولى ايجاد طرق لعلاج الامراض ثم التفكير بإطالة العمر ، لكنني ارى انه الاتجاه بصوب طرق اطاله العمر سيجعل الطرق صحيحه لعلاج الامراض او تأخير ظهورها وهذا ما يؤكده الكثير من خبراء الصحة فلا ينبغي علينا اهمال صيانه العربة او اساءه استخدامها لكي لا تذهب لإصلاحها ودفع مبالغ باهضه لإصلاح ، بالرغم من ان منظمه الصحة العالمية وحتى مصدري الطب الحديث على استحياء من تغير توجيه توجهاتهم للاعتماد على اساليب اطاله العمر خاصة أن مجمل العالم مازال فقير، فكثير من دول العالم لم تحصل على اساسيات الحياه مثل المنازل الحديثة او الصرف الصحي او الماء الصالح للشرب او حتى الاطباء او الدواء الا انه من اهم مؤشرات سعادة الدول المتقدمة هو طول العمر بالإضافة الى الدعم الاجتماعي وقله الفساد والناتج الاجمالي والمحلي للفرد وهو ما يتسابق عليه الدول المتقدمة ، وهذا لا يعني ان اطاله العمر تحتاج ان تكون ثريا بالضرورة فنجد كثيرا من المعمرين هم المتوسطين الدخل ولكن تسخير المال من اجل صحه افضل هو من الممكن والمناسب جدا ، وان توصلنا اليوم لحلول لاطاله العمر سنفكر لاحقا لحلول للخلود وان لم نبدأ لم نصل ، وبالفعل تجد ان الصين واليابان وكوريا وسنغافورة وامريكا الشمالية واستراليا واوروبا بفعل تقاليدهم الغذائية والصحية القديمة او الحديثة قد حققوا نتائج في اطاله العمر والصحة ، حتى ان بعض الشعوب العربية ذات الحضارة قد اكتسبت بعض العادات الغذائية و الأطباق و الوصفات الشعبية ، فمثلاً الاكثار من استهلاك زيت الزيتون والحامض والبقوليات دون غيرها من الشعوب هو دليل على التقدم الفكري والوعي الصحي، فطرق الطهي و اعداد الطعام التاريخية و التراثية التي لم تأتي من المختبرات او مراكز بحثيه هو دليل على الوعي و التقدم ، و على الرغم من التقدم العلمي الذي وصل لمرحله زراعه و تخليق الخلايا الجذعية وغير الجذعية والخرائط الجينية و الطب الدقيق و الشخصي ، إلا انه مازال نوع الغذاء و كمه من اهم العوامل التي تحدد صحته وطول العمر ، لذا ان الدقة في انتقاء نوع الغذاء من رفوف المتاجر افضل من الدقة في انتقاء نوع الدواء من ارفف الصيدليات ، فعمل على طلب الاطلاق الصحية من نادل المطعم بدل من طلب الدواء من الطبيب ، واتبع تعليمات مدرب اللياقة البدنية بدل من اتباع تعليمات الطبيب ، فليست المشفى بفندق وليس الدواء طعاما فالرعاية الصحية لا تحرز سوى 10% من المحافظة على الصحة او اطاله العمر و 50 % تحدده عوامل جينية و 40 % تحدده عوامل اجتماعيه ، لذا من المهم الانتباه للعوامل الاجتماعية وهي خبرات الطفولة المبكرة ، التعليم ، بيئة العمل ، دعم الشيخوخة ، موارد المجتمع مثل الطعام الصحي و وسائل النقل و ضمان السكن و وسائل الترفيه و الحماية البيئية و الوقاية من العنف و العدالة .

كنت أظن عندما دخلت كليه الطب ان للطب دور اكبر ولكن الان اصبحت واعتقد ان الطب يجب ان يتطور كما حدث من تطور في العلوم الصناعية ، لذ ابحث عن ما هو غير معلوم وغير متوقع وابدأ باكرا خاصه في مجال اطاله العمر فإيجاد طريقه لاطاله العمر اسهل بكثير من ايجاد دواء لعلاج مرض خبيث او صعب ، و أعلم أن حقيقة الارتفاع الطفيف في متوسط العمر لدى بعض الشعوب لا يرجع لإنشاء مئات المستشفيات والاطباء والصيدليات بالمقام الاول ولكن لتوفر الماء النظيف والمنازل الحديثة و وسائل الترفيه وسائل التدفئة والتبريد والظل والصرف الصحي اكثر مما كان سابقا هي العوامل التي تزيد متوسط العمر ، ويشير الكثير من خبراء اطاله العمر انه لو تم التوجه لتبني سياسات اطالة العمر داخل المنظومة الصحية فسيقل الإنفاق و يقل او يتأخر ظهور الأمراض ، و بعض الافراد يؤمن بان تناول تفاحة يوميا قد يجنبه زياره الطبيب والبعض يؤمن بان شرب الماء مع الليمون صباحا كعادة يوميا ايضا قد يجنبه زياره الطبيب والكثير و الكثير من النصائح الطبية المتداولة ستجدها على التلفاز أو مواقع البحث و هي فعالة في بعض الاحيان ، ان اكثر المتعلمين تعلماً جيدا يعلم كيف العناية بحديقة المنزل ثم تناول طعامه من حديقة المنزل ثم اصبح بصحه جيده ستجد الكثير من القنوات على مواقع اليوتيوب تعلمك الزراعة المنزلية ولعلها وسيله جيده للترفيه وايضا للصحة وتوفير المال ، واحرص دائما على ان تكون السلع الغذائية الأساسية هي سلع غذائية مفيدة حتى وان كان الموروث او السائد لا يجذبك الى ذلك ، فاهم ما على الفرد هو تعلم الزراعة والرعي والطهو وهذا ما غاب عن المجتمعات التي تسعى ان تكون حديثه شكلاً ولكن هي بالمضمون تتجه للوراء ان لم تكن على وعي بضرورة المحافظة على سبل العيش وتطويرها ، فكما ان المجتمعات الحديثة قد اكتسبت سبل الراحة فعليها ان تتأكد من ان هذه السبل لن تتعارض مع سبل الصحة فالبعض ينتعش عند شرب الكوكا صباحا ومساء والبعض ينتعش عند شرب عصير الليمون صباحا ومساء والبعض فقد لياقته البدنية بسبب وسائل النقل والبعض بقي نشيطا وهو يذهب للحقل او صيد السمك .

السر الأول

لا ينبغي ان يكثر الفرد من تناول الفاكهة الحلوة ان لم نقل السكر ولا ينبغي له ان يهمل جذع الشجرة وجذورها فلعل لب النخيل أو جذور نبته الجنسينج او نوى التمر قد امتصت وتركز بها خيرات التربة من معادن واملاح اكثر مما هو في الثمرة ، وكثير من خبراء التغذية ينصح بتناول قشور الفاكهة او البذور كبذر اليقطين ان لم تتلوث بمبيد او سماد ، كذلك لا ينبغي ان تنفر من ماء البئر او جدول المياه وتفضل مياه التحلية ان بعض المعادن المهمة للجسم كالليثيوم و السليكا واليورانيوم والملوبيديوم و غيره يكون تركيزها اكثر بالتربة مما هو عليه في الطعام ، كذلك الحيوان في الغاب يشرب من مياه البركة العكرة بالطين فيعمر ويعيش اطول من ان يكون في حديقة الحيوان ، كذلك بعض الأطعمة تحتوي على نسبه اشعاع منخفضه مثل الجوز البرازيلي ، الفاصوليا ، الموز ، الجزر، البطاطا ، القهوة البنجر، الشوكولا وايضا الطحالب البحرية ذات تركيز من ليثيوم البحر، وكلما كانت التربة الزراعية اكثر احتواء على المعادن كلما كانت ثمار الاشجار اكثر فائدة واكثر عمرا وقديما تداول البشر بالطين والرماد كطين خاوه ولا يزال الكاولين يستخدم في مكونات الدواء والطين الطبي الالمانيhellerde luvos يستعمل كمكمل غذائي ، ان الردم بالرمال او التلطخ بالطين واندماج الطين والرمال مع اشعه الشمس او الحرارة سيولد اشعاعا وطاقه مفيدة لترميم الخلايا ، كذلك تؤثر حجاره البناء على صحه الانسان فأصحاب المنازل الحجرية غالبا سيعمرون وسيتمتعون بعافيه اكثر من اصحاب المنازل الإسمنتية ، ويرجع ذلك لان تعامد اشعه الشمس مع الاحجار سيولد طاقة اشعاعية طفية داخل البناء وهي ذات اهميه لتوليد خلايا قوية ، ولعل غاية بناء الاهرام بذلك الحجم الكبير والغرف المعتمة كان غايته اطاله العمر بحجب الاشعاع الضار وتوليد اشعاع من التراب والاحجار موجهه داخل غرف الاهرامات ، ان الجيل الذي عاصر ظهور الكهرباء والموبايل كان اكثر حيوية وجنونا ، ولعل هذا يستدعي ان علينا البحث لتسخير الكهرباء اكثر مما نتوقع من الكيمياء لتنشيط الجسم واطاله العمر ، ظهرت بعض التقنيات مثل العلاج بالأشعة الحمراء red light therapy أيضا العلاج بالمجال الكهرومغناطيسي pulsed electromagnetic field therapy PEMF

１. الزنجليل

２. الليمون

３. الخرشوف

４. مادة الكولين

５. الكركم

６. الطرخون

７. مادة بيتين

８. الشمندر الأخضر

９. حليب الشوك

１０. الأحماض الصفراوية مثلTUDCA

السر الرابع

جلطات الشعيرات الدموية بخلايا الدم الملطخة بالسكر و الكولسترول الدبق ما سيؤدي إلى اندثارها ، إن حالة القلب و ضغط الدم تتأثر غالباً بقدر ما يستطيع تصريفه من الدم من خلال الشعيرات الدموية الدقيقة عند الالتقاء الشرياني الوريدي التي تتخلل الأنسجة و الأعضاء ، فكلما كان العضو ذا مرونة و نفاذية و أقل التهاب و تليف كلما كان انغماس الشعيرات الدموية أسهل و أكثر ، يحتوي جسد الإنسان على مليار شعيرة دموية و تقل و تندثر مع التقدم بالعمر ، و قد يعود تفسير ذلك لعملية تسمى الغلوزة glycation وهي عبارة عن التصاق السكر الدبق بالبروتين ما ينتج عنه تكتلات و خثرات صعبة التحلل و الاستحلاب داخل شعيرات الجسم ، و قد يحتاج القلب لزيادة ضغط التدفق لتعويض هذا الانسداد الجزئي أو من خلال توليد أوعية و شعيرات angiogenenesis حال توافر عوامل نمو ، و يعود تفسير أن الفائدة من استخدام NAD أو NMN أنها تعمل على تعزيز عملية تولد الأوعية angiogenesis ما يساهم بالحفاظ على العضلات و الأعضاء بحالة تروية جيدة وايضا ضمان عدم التصاق الألياف العضلية بالأخص ما سيوفر كميات متوازنة جيدة من اليوريا التي بدورها ستساهم بالحفاظ على بروتينات الجسم دون تمسخmisfolding protein

السر الخامس

إن التعود على مقدار منخفض من الاكسجين الجوي كالعيش في المرتفعات سيجعل الجسم الميتوكونديريا قادره على تعويض هذا النقص من الاكسجين ، قد يستخدم بعض الخبراء اللياقة البدنية مقياس سعة الاكسجين القصوى v o2 max ومحاوله العمل على تحسين هذه القيمة ، ولكن يوجد أيضا من يستخدم العلاج بضغط الاوكسجين المنخفض والتناوب مع المرتفع hyperbaric oxygen therap ،او التناوب بالعيش فترات في اماكن مرتفعة قليلة الاكسجين واخرى منخفضه عالية الاكسجين ، وتبقى ممارسه التدريبات المتواترة عالية الكثافة

High intensity interval training

من خلال الدراجة الثابتة بحيث تكون هناك فترات متناوبه من ثلاث الى خمس دقائق يصل بها ل 95 الى 90% من الحد الاعلى لمعدل ضربات القلب عند ممارسه الرياضة بناء على العمر HR max ,ويمكن حساب المعدل الاقصى لضربات القلب من خلال معادله حسابيه

208-(0.57× age)= HR max

و كلما استطعت من دقائق أثناء التمرين البقاء على معدل ٩٠ بالمئة من معدل ضربات القلب القصوى HR MAX كلما تحسنت قدرة الميتوكونديريا على انتاج الطاقة و تحسنت الدورة الدموية بشكل عام .

السر السادس

براز بكتيريا الامعاء والكانديدا هو الغذاء المناسب ، على الرغم من توافر اصناف الطعام الشهية وذات المذاق الجيد الا انه البنيه التراكمية لمواد هذا الطعام قد تضر الجسم، فكما انها ستفسد خارج الجسم كذلك هي ستفسد ويتغير تشكيلها البنيوي داخل الجسم لذى كل ما كانت ذات صلاحية خارج الجسم كلما كانت ذات صلاحية داخل الجسم ، خاصه المواد البروتينية منها فمثلا تستطيع الاحتفاظ بالعدس خارج الثلاجة لفترة طويله لكن قطعه اللحم او الحليب سريعا ما سيفسد ويتلف خارج الثلاجة ، لذ نجد ان المطبخ الاسيوي بقصد او بدون قصد اعتمد على الأغذية المخمرة والبعض على المقدد على الرغم من رائحتها غير المستساغة ،الا انه عندما تتناول طعام فاسد خارج الجسم ستضمن انه لن يفسد داخل الجسم و يغير من تركيبته البنيوية ، وكثير من الطعام عندما يصل للأمعاء سيحدث له كما حدث في عملية التخمر الذي سيستخدمه المطبخ شرق اسيوي بشكل اكثر واكثر عفونة خاصة لمن يعتد على طعام به النشا و الألياف بكميات قليلة التي هي غذاء لبكتيريا الأمعاء ،بالتاكيد هناك بعض انواع البكتيريا طغى اثاره النافع مثل اللاكتوباسيلس على أثرها الضار ، هذه البكتيريا النافعة بالأمعاء بمثابه مزرعة اسماك صناعية يجب الحرص على نوع طعامها و محيطها لتتكاثر ، وايضا هي بمثابة جهاز هضم احتياطي ثانوي ستقوم بالعمل على جعل مركبات الطعام بسيطة وبصوره نهائية لا فساد او تعفن بعدها .

السر السابع

الحجامة والفصد ، في حين ان عمليه التئام الجروح هي افضل مثال على قدره الشفاء الذاتي ، كذلك وجد ان عمليه التئام الجروح والاصابات تتطلب اطلاق ذاتي لبيلتيدات peptides وعوامل النموgrowth factors للشفاء ، ففي حين انه تم استعمال peptide BPC157 كمساعد لعامل النموVEGFR2 و مساعد لعمليه التئام الجروح وزياده سماكه الامعاء ، الا انه وجد ان الحجامة المنتظمة كذلك ستساعد بإطلاق بيبتيدات النمو وقد تكون اكثر امانا حين لا يخشى منها كمسبب لنمو سرطاني ، وكذلك الحجامة ستزيد من كريات الدم البلعمية ومستويات متوازنة من الهستامين ويؤكد البعض فوائد التبرع بالدم بشكل دوري ، وكان الفصد طريقه علاجيه منذ الأزل ولعله يعمل على تنشيط نخاع العظم للاستمرار ونشاط صنع خلايا جذعية

السر الثامن

افضل طريقه مراقبه التقدم بالعمر هي ما تراه لا ما تعطي نتائجه المختبرات ، فبالرغم من ان كثيرا من المختبرات اصبحت تعمل على تحديد العمر البيولوجي من خلال قياس DNA methylation test

الا انه ليس بذا مقياس للشيخوخة تحديداٌ، قد يكون شكل البراز ولونه او قدره تركيز النظر نحو الاشياء القريبة او مستوى السكر والدهون بالدم او اختبار AGE readerاو مقدار الكتلة العضلية اكثر دقه لتحديد درجه الشيخوخة

د.عبدالعزيز عبدالغني الفتيح

كيف نصل لاكسير الحياة ؟

اذا انه لم يرصد حتى الان أحد من الذين تجاوزوا المئة عام انه استعمل اي مكمل غذائي او فيتامين لإطالة العمر ، فكيف نستطيع ان نجزم من ان NMN او Rapamycin او Metformin و غيرها هي وسائل لإطالة العمر ، وعلى الرغم من التجارب التي اجريت على الفئران واستخدم بها مادة NMN واثبت انها تطيل العمر بمقدار لا يتجاوز عشرة بالمئة بإطالة العمر ، وهذه كانت من انجح التجارب حول هذا المجال خاصه ان الفئران هي من الثدييات الا ان الفئران لا تتشابه مع الانسان تماماً، لذا انه من المبكر جداٌ الجزم بان دواء او ماده قد تطيل العمر ، وهذا ما سيتجلى ويصبح واضحاً بالخمسين أو الثلاثين سنه القادمة ، اذا ما زالت الحياة على كوكب الارض ، ولو حدث واثبت ان هناك مادة تطير لعمر الانسان فان الدول والمنظمات الصحية ستصبح مجبرة على توفير هذه الطريقة بأرخص الاثمان فقد نرى يوما ما ان سعر NMN اصبح ارخص من سعر الاسبرين أو أنه يصرف مع التأمين الصحي ، ولكن هل هذا ما يتوقع ام ان الاحتكار و ابقاء اكسير الحياه مستقبلا سيبقى لمن يملك ثمنه الباهض ، وهل ستستفيد الدول الفقيرة من ابحاث طب اطاله العمر ؟ ام انه يكفي لهم توفير الدواء للأمراض الشائعة ، وحتى هذه اللحظة لمن نشاهد مظاهرات في الدول الفقيرة تطالب بتوفير الفيتامينات والمكملات الغذائية المتعلقة بإطالة العمر ، بالطبع انه من الباكر الحديث عن ذلك ، ولكن ما يثير الشكوك هو الاسعار الباهظة ل NMNو Rapamycin و SARMS و peptidesوتفاوت اسعار المكملات الغذائية ، فبعض المكملات الغذائية اسعارها رخيصة وبعضها اسعارها باهظة ، ما الذي يحدد ذلك ؟ وهل ينبغي ان يكون هناك عدالة في الاسعار وتوزيع المكملات الغذائية على الاسواق العالمية ؟ وهل ينبغي ان يساعد المبتكرين مصانع الدواء بالسماح لها بتوفير المكملات الغذائية بأسعار زهيدة ؟ ام ان هناك تنافس على الارباح وحصد الميداليات الاولمبية ‼ من وجهة نظري انه وان اردنا الوصول لاكسير الحياة فعلينا ان نزيد عدد المستخدمين المشاركين بالابحاث وكيفيتها لتعطي نتائج دقيقة بالجزم من فائده المكمل الغذائي من عدمه في اطاله العمر

اذا سنحصل على اكسير الحياه عندما يصل و يصبح بمتناول الجميع .

د.عبدالعزيز عبدالغني الفتيح

Longevity month 2022

September 18, 2022Advocacyilia2014

On Saturday, October 1, 20.00 CET / 18.00 UTC, the International Longevity Alliance (ILA) conducts an open ILA meeting in honor of the International Longevity Day – October 1, the beginning of the International Longevity Month!

This year it will be the 10th year since ILA initiated the Longevity Day/Month campaign in 2013. So, on Saturday, October 1, the ILA will mark this anniversary in an open meeting – for ILA members and others interested in longevity activism, including presentations on Longevity Activism (experience, actions, plans).

Several presentations by ILA core activists are in the program: by Daria Khaltourina, Edouard Debonneuil, Didier Coeurnelle, Angel Marchev Sr., Osinakachi Akuma Kalu and Brenda Ramokopelwa, OsinaIlia Stambler. Additional presentations are possible. Also, longevity activists to briefly tell some of their activism experiences, news and plans, and present themselves during the meeting.

Recordings from the conference can be found at the ILA youtube channel:

https://www.youtube.com/playlist?list=PLL_98VMxZR2yrAjN7bJwF-1CVUXC0-PC7

Registration form

In addition, a series of Longevity Days events during the Longevity Month of October in Italy has been organized by the Italian Longevity League (ILL), an ILA federated member.

https://en.italianlongevityleague.com/general-6

As well as in Pakistan by the National Academy of Young Scientists, at the National University of Science and Technology in Pakistan

https://www.facebook.com/events/1595314390897223/

More longevity conferences were organized in October, such as:

The RAAD fest, in San Diego, California, USA, on October 6-9. https://raadfest.com/

The 2nd Mediterranean congress of anti-aging medicine 2022, on October 14-16, at Larnaca, Cyprus. https://mcamcyprus.org/

The Rejuvenation Startup Summit, on October 14-15, in Berlin. https://forever-healthy.org/summit/

JAIN China & ISOAD Summit 2022: AI & Cognitive Science – Aging and Disease.

A hybrid conference, Shanghai and online – October 27-30, 2022

Live streaming (including the video recording of the entire conference, see in particular Oct 29 presentations dedicated to aging and disease) https://lm.enewie.com/live/YCYYKJ

Program: JAIN ISOAD Conference Program 27-30 October 2022 Final

Additional information about the JAIN-ISOAD summit http://www.jainchina.com/

https://www.youtube.com/channel/UCTgNRCH86XAlFzv9kYEzWBg

If you organize or participate in additional events for Longevity Day/Month, please let know, and we will add those events to the general reports about the global Longevity Day / Month actions that we keep since 2013 (so far there were hundreds of events in dozens of countries).

http://www.longevityhistory.com/longevity-day-and-longevity-month/

Looking forward to the Longevity Day!

Healthy Longevity for All through Scientific Research!

ILA board

#longevityday #longevitymonth #longevity #research #advocacy #education #activism

Longevity School of the Italian Longevity Alliance

August 24, 2022Advocacy, Italian Italianoilia2014

The Longevity School of the Italian Longevity League (ILL) is to open soon and now conducts pre-registration.

The teaching will be done in Milan, in Italian.

The International Longevity Alliance (ILA) endorses and supports this initiative!

Details on the School program and registration:

https://www.italianlongevityleague.com/school

https://www.italianlongevityleague.com/

https://en.italianlongevityleague.com/training

PROGRAM ENGLISH – ITALIAN LONGEVITY LEAGUE – HIGHER EDUCATION SCHOOL IN LONGEVITY MEDICINE

The ILL scientific board

https://en.italianlongevityleague.com/copia-di-coorporate-list

Aging is a medical target in ICD-11 with 2 codes

July 8, 2022Advocacy, Scienceilia2014

An update on the recognition of aging as a treatable medical condition in the ICD:

In the current International Classification of Diseases (ICD-11) system, for the code MG2A, the original main designation “Old age” is now fully replaced with the new one: “Aging-associated decline in intrinsic capacity” in the “General Symptoms” category (the change is now also seen in the main ICD website)!

https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/835503193

The new designation is even better for designing measurable interventions into aging than the previous ill-defined “Old age”.

Moreover, there are about 14 “matching terms” for this MG2A Code, including “frailty of old age”, “old age atrophy”, “old age exhaustion”, “old age debility” and also “ageing” itself! All these terms allow the direct targeting of aging as a medical condition or as a set of general medical symptoms!

https://icd.who.int/ct11/icd11_mms/en/release (search “ageing”)

Moreover, there is a second code in the ICD-11, the XT9T extension code “Ageing-related” in the “Causality” or “Aetiology” category which also permits targeting aging as a medical indication, namely as an underlying cause or risk factor of diseases.

https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/459275392

Thus, with both codes, Aging can be now directly targeted by biomedical interventions in accordance with the present International Classification of Diseases (ICD-11).

The contribution of longevity research advocates to this inclusion of aging into the ICD-11 as a treatable medical condition has been crucial.

Now the task is in the hands of medical researchers and practitioners to leverage those ICD codes to design and test interventions directly into aging, including the development of evaluation criteria for the efficacy and safety of such interventions, for the benefit of older persons, prevention of aging-related diseases and extension of healthy longevity!

See our brief article, explaining the principal topics about the inclusion of Aging in the ICD-11:

Ilia Stambler, Aleksey Alekseev, Yuri Matveyev, Daria Khaltourina. Advanced pathological ageing should be represented in the ICD. The Lancet Healthy Longevity, 3(1), E11, 2022. https://doi.org/10.1016/S2666-7568(21)00305-6

Also recently, additional articles on the subject were published in The Lancet Healthy Longevity:

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00154-4/fulltext

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(22)00102-7/fulltext

Support Mechnikov Fund in Ukraine

March 14, 2022Ukrainian Українськаilia2014

Update (July 1, 2022): Presently, the collection of donations is suspended, due to the difficulties of transfer into a Ukrainian branch of a Russian bank. Further details concerning the support of the Metchnikoff educational fund will be forthcoming. Obviously, the education about Metchnikoff’s legacy will be relevant long time after any temporary troubles are over.

14 March 2022

Below is a request of support for the “International fund of memory І.І. Mechnikov” located in Slobozhanshina (Kharkov District, Ukraine, Mechnikov’s birthplace) that works to maintain and popularize the cultural and scientific legacy of the Nobel Laureate in Medicine, the founder of gerontology and cell immunology Ilja Mechnikov and promotes scientific education in Ukraine (in biology, ecology, history etc.) via the Mechnikov Museum that they maintain in Dvorichna, Kharkov District, field research, young talent competitions, lectures, conferences and round tables, book publications, etc. (and now also help for the local population in need) http://mechnikov.dvorichna-vo.gov.ua/

Thanks for your support in this time! Below is their letter and support details. Thanks!

“Dear scientists, workers of culture and art and all the indifferent people!

The organizing committee of Charitable organization “International fund of memory І.І. Mechnikov” and compatriots of outstanding scientist and Nobel Prize Winner from Slobozhanshina (Kharkov District, Ukraine) apply to you for help.

The aim of the fund was to perpetuate the memory of our outstanding compatriot Ilja Mechnikov, who initiated the fight for health and long life of the mankind. Now we live in the hard time of devastation, horror, lack of medicine and food products. The humanitarian catastrophe is nearing. Now its the hard time for us to help the Ukrainian people, especially women, children and aged people to overcome the terrors of war. We are ready to organize through volunteers the help for all who need it.

Our bank details:

Download

Letter from Ilja Mechnikov Fund

Beneficiary’s name: Charitable organization “International fund of memory І.І. Mechnikov”. Bank name: JSV “ALFA-BANK”, Ukraine, Kiev. IBAN: UA793003460000026002094642201. Bank code : 42616257

Head of Charitable organization “International fund of memory І.І. Mechnikov”

Olga Berveno.

09.03.2022

Address:

“International fund of memory І.І. Mechnikov”

Kolomenskaja str.25 ap76

Kharkov, Ukraine 61166

Contact phone: +380985955550

“Шановні науковці, діячі культури, мистецтва і всі небайдужі люди!

До вас звертається оргкомітет благодійної організації міжнародний фонд пам’яті Іллі Ілліча Мечникова, земляки великого вченого і Нобелівського лауреату Слобожанщини (Харківська область, Україна). Завданням фонду було вшанування пам’яті нашого знаменитого земляка – Іллі Мечникова, людини, яка започаткувала боротьбу за здоров’я і довголіття людства. Зараз у нас тяжкі часи- розруха, страх, відсутність ліків та продуктів харчування. Наближається гуманітарна катастрофа. Тепер наш час допомогти українцям-жінкам, дітям, людям похилого віку, пережити страхіття війни. Ми готові організувати через волонтерів допомогу всім, хто її потребує.

Наші реквізити:

Download

Лист фонду Мечникова

Голова благодійної організації „Міжнародний фонд пам’яті Іллі Ілліча Мечникова”

О.М. Бeрвено

09.03.2022

Адрес

„Міжнародний фонд пам’яті Іллі Ілліча Мечникова”

Ул. Коломенская д.25 кв. 76

г. Харьков, Украина 61166

Контактный телефон +380985955550

ILA yearly report 2021

February 21, 2022Advocacyilia2014

The International Longevity Alliance (ILA) presents its yearly report for 2021.

In 2021, ILA continued to advance its mission of promoting “healthy longevity for all through scientific research”. Conducting promotional activities was not easy in this period. Yet, in 2021, ILA remained active.

In 2021, ILA increased its federated membership to 33 registered non-profit associations from 26 countries as federated members.

http://www.longevityforall.org/groups/

Most recently, 3 associations from Canada joined: Canadian Longevity Association (CLA), Lifespan Society of British Columbia, and Vitality Healthspan Foundation.

http://www.longevityforall.org/groups/

In 2021, the ILA organized and co-organized and/or was strongly represented in a dozen online longevity conferences, especially during October, “the Longevity Month”, organized by core ILA members in several countries, with international participation, including: Slovenia, Belgium, Nigeria, Bulgaria, Brazil, Malaysia, US, Spain, India, Russia, Israel.

https://longevityalliance.org/organization/1/post/25

Furthermore, ILA continued its scientific activities as well as activities for the promotion of science.

https://longevityalliance.org/organization/1/post/24

Analytical summaries have been published, such as

“Anti-aging treatments against COVID!?”

https://longevityalliance.org/organization/1/post/26

Moreover, the ILA launched a worldwide and unlimited collaboration, based on open data, to collectively see how to improve health worldwide. The initiative is entitled OpenData4Health, and welcomes any volunteer and any institution to join the project! The initiator is an ILA board member Dr. Edouard Debonneuil. Instructions are at:

http://OpenData4Health.org

https://longevityalliance.org/organization/1/post/27

The results of ILA-initiated studies of potential geroprotective therapies in mice have been reported in the scientific literature. Thus, a recent study explored the effect of the potential geroprotective drug C60: Dmytro Shytikov, Iryna Shytikova, Deepak Rohila, Anton Kulaga, Tatiana Dubiley, and Iryna Pishel. Effect of Long-Term Treatment with C60 Fullerenes on the Lifespan and Health Status of CBA/Ca Mice. Rejuvenation Research, 24(5), 345-353, 2021. https://www.liebertpub.com/doi/10.1089/rej.2020.2403

https://www.indiegogo.com/projects/i-am-a-little-mouse-and-i-want-to-live-longer#/

An additional research study on the use of senolytic drugs for healthy longevity in mice, co-organized by ILA and Leipzig university, under the direction of Dr. Alexandra Stolzing, is now in the final stages of preparation.

https://web.archive.org/web/20161031103116/http://longevityalliance.org/?q=longevity-activists-call-support-investigation-drugs-against-aging

https://web.archive.org/web/20201026153126/http://longevityalliance.org/?q=mmtpsenolytics-second-dosing-september

In 2021, ILA together with HEALES, co-sponsored additional mouse lifespan trials, at the initiative and by the support of an ILA board member Didier Coeurnelle https://www.theworldhour.com/heales-co-chair-didier-coeurnelle-donates-50000-for-life-extension-research/

As well as the Longevity Hackathon https://longhack.org/

A strong focus of ILA scientific activities has been on developing clinical evaluation criteria for aging and aging-related diseases.

For example, ILA experts, an ILA board member Dr. Ilia Stambler and an ILA scientific advisor Dr. Alexey Moskalev, initiated, under ILA affiliation, a special research topic on clinical evaluation criteria of aging and aging-related diseases, in the scientific journal Frontiers in Genetics: Genetics of Aging. 9 scientific articles have been published in this research topic by internationally acclaimed scientists, as well as an e-book, and summary by the ILA expert editors.

https://www.frontiersin.org/research-topics/14483/clinical-evaluation-criteria-for-aging-and-aging-related-multimorbidity

https://www.frontiersin.org/articles/10.3389/fgene.2021.764874/full

And perhaps most importantly, in a large measure thanks to the years-long advocacy of ILA members, especially an ILA board member Dr. Daria Khaltourina, since January 1st, 2022, “aging” is officially included in the International Classification of Diseases (ICD-11) under 2 categories: “symptoms” and “causality”.

Please read about this inclusion in the article by the ILA board members Daria Khaltourina and Ilia Stambler, published in The Lancet Healthy Longevity, entitled “Advanced pathological ageing should be represented in the ICD”

(free and open access)

https://linkinghub.elsevier.com/retrieve/pii/S2666756821003056

As well as this explanation https://www.longevityforall.org/advanced-pathological-ageing-should-be-represented-in-the-icd-lancet-healthy-longevity-january-2022/

This is the kind of achievement that ILA was created and existed for! And it gives encouragement for more activities and achievements in the future!

The ILA continues its operation. On January 29, 2022, the annual ILA general assembly took place, and confirmed 8 ILA board members, representing 8 of the ILA federated members. 5 federated members will serve a new two year term in the board: Maria Entraigues Abramson – SENS Research Foundation (US); Walter H. Crompton – American Longevity Alliance (US); Didier Coeurnelle – AFT Technoprog (France); Alexander Tietz-Latza – HEALES (EU); Martin Lipovšek – Society for Vital Life Extension (Slovenia). There will remain 3 federated members to serve for another year of their 2 years term: Daria Khaltourina – Council for Public Health and Problems of Demography (Russia); Edouard Debonneuil – Longevite & Sante (France); Ilia Stambler – Israeli Longevity Alliance (Israel). https://www.facebook.com/InternationalLongevityAlliance/posts/4626370860822524

Looking forward to a new productive year for the ILA!

ILA board

20 Years of Longevity Activism

January 20, 2022Advocacy, Scienceilia2014

Making a little personal celebration: 20 years of involvement in longevity or life extension activism. 10 years ago, by January 2012, I completed my PhD thesis on the “History of Life-extensionism” and co-organized our first demonstration for life extension (on January 20, 2012) and since then became fully involved in longevity or life extension activism. And 10 years before that, around January 2002, after completing the MA, I started to work as a science writer in biotechnology and co-created our first multi-lingual site on life extension, and so became partly involved in longevity (life extension) activism. In these 20 years, one could see the massive shift of public attitude in favor of the possibility and desirability of healthy life extension, hopefully at least in some small measure also thanks to our activism. But still there is a lot of work to be done to bring this possibility and awareness closer to real implementation, to the actual achievement of aging amelioration and healthy life extension (and not a lot of time to do it…). Below are some highlights, summaries, references and pictures from those years.

Ilia Stambler

January 20, 2022

1. February-March, 2002. Co-creation of the first multi-lingual site on life extension “Elysian Enterprise”

https://web.archive.org/web/20031022205308/http://elysianenterprise.com/russian/chapters/medicine_science.html

https://web.archive.org/web/20030722093218/http://www.elysianenterprise.com/

2. January 27, 2006. Organizing the first live ImmInst/WTA meeting on life extension in Israel in Bar Ilan University

https://www.longecity.org/forum/topic/9057-1st-isr-imminstwta-mtng-jan27-1030-biu/

3. September 12, 2006. Co-signing the first Longevity Dividend petition.
https://deepblue.lib.umich.edu/bitstream/handle/2027.42/75679/annals.1396.050.pdf?sequence=1
http://www.longevityforall.org/wp-content/uploads/2014/05/Longevity_Dividend_Signatories.pdf

4. 2006-2010. Organizing a series of seminars on life extension/transhumanism in Bar Ilan University (November 6, 2010, the 10^th seminar since 2006)

http://www.singulariut.com/2010/11/260

https://www.singulariut.com/2020/10/3571

https://www.haaretz.co.il/science/1.1196720

https://archive.ieet.org/articles/pellissier20100820.html

5. October 16-27, 2011. First broad public and academic conferences on life-extension and transhumanism in Israel, in Tel-Aviv Cinematheque, Hemda Science Teaching Center in Tel Aviv and Van Leer Institute in Jerusalem

http://www.singulariut.com/2011/10/325

https://archive.ieet.org/articles/stambler20111101.html

https://www.facebook.com/Utopiafest.org.il/photos/t.672869158/10150390819607668/?type=3

https://archive.ieet.org/

6. January 20, 2012 Demonstration for life extension, Tel Aviv

http://www.singulariut.com/2012/01/510

https://web.archive.org/web/20121023145203/http://ieet.org/index.php/IEET/more/stambler20120126

7. February 27, 2012. Advocacy in Knesset for establishing the “Israel National Advisory Committee for the Struggle against the Disease of Aging”

http://www.singulariut.com/2012/07/601

https://web.archive.org/web/20120720024947/http://ieet.org/index.php/IEET/more/stambler201207171

8. July 17, 2012. Publication at Institute for Ethics and Emerging Technologies (IEET) of the article “Political Struggle against the Disease of Aging” describing the first efforts of high level longevity advocacy in Knesset

http://www.singulariut.com/2012/07/601

https://web.archive.org/web/20120720024947/http://ieet.org/index.php/IEET/more/stambler201207171

9. July – August, 2012. Co-creation of the International Longevity Party

https://web.archive.org/web/20120901111034/http://ieet.org/index.php/IEET/more/6354

https://web.archive.org/web/20121023133820/http://ieet.org/index.php/IEET/more/6377

https://archive.ieet.org/articles/stambler20120823.html

https://web.archive.org/web/20181009064319/https://ieet.org/index.php/IEET2/bio/stambler/

10. June 28, 2012. PhD Graduation. Department of Science, Technology and Society, Bar Ilan University. Thesis subject: “A History of life-extensionism in the twentieth century”

http://www.longevityhistory.com/

https://www.ishps.org.il/blank-9

https://www.sts-biu.org/alumni

https://www.sts-biu.org/post/2018/04/28/april-28-healthy-longevity-promotion-multidisciplinary-perspectives-dr-ilia-stambler-bar

11. August 29, 2014. Publication of the book: “A History of Life-extensionism in the twentieth century”

http://www.longevityhistory.com/

https://www.amazon.com/History-Life-Extensionism-Twentieth-Century/dp/1500818577

12. December 14, 2012. Gathering of the International Longevity Alliance activists at the Eurosymposium on Healthy Ageing, in Brussels, Belgium

https://hplusmagazine.com/2012/12/19/the-brussels-summit-of-longevity-activists/

13. July 2012-2013. Developing International Longevity Alliance (ILA)

www.longevityalliance.org

https://www.longevityforall.org/groups/

https://web.archive.org/web/20140112094026/http://ieet.org/index.php/IEET/more/stambler20140110

https://longevityalliance.org/about/history

https://en.wikipedia.org/wiki/International_Longevity_Alliance

14. March 10-13, 2013. The 8^thEuropean Congress of Biogerontology, Beer Sheva, and events and media promotions of longevity in Tel Aviv

http://www.mako.co.il/news-channel2/Weekend-Newscast/Article-5552ae448947d31004.htm

https://www.israel21c.org/israelis-excel-in-finding-keys-to-long-life/

15. September 3-7, 2013. Sixth SENS Conference (SENS6). Reimagine Aging. Queens’ College – Cambridge UK

https://www.liebertpub.com/doi/10.1089/rej.2013.16.sens6abs

https://www.youtube.com/watch?v=EoBkf8rEGOo

16. October 1, throughout October, 2013-2021. Longevity Day and Longevity Month Campaign to raise awareness and support for healthy longevity research

https://www.facebook.com/LongevityDay

http://www.longevityhistory.com/longevity-day-and-longevity-month/

https://hpluspedia.org/wiki/Longevity_Day_and_Month

17. March 26, 2014. Pathways to Healthy Longevity. Israel Science Day. Bar Ilan University, Ramat Gan, Israel, additional events and media promotions of longevity research in the framework of Israel National Science Day.

https://www.ynet.co.il/articles/0,7340,L-4503579,00.html

https://youtu.be/fwO_jaffJh4

https://www.israel21c.org/rd-for-the-elderly/

18. January – February 2016. Co-organizing the Global Healthspan Policy Institute (GHPI), Washington

https://healthspanpolicy.org/person/ilia-stambler/

https://healthspanpolicy.org/public-policy-implications/

19. September 21-22, 2016. 3rd International Forum on Practical Applications for Aging Research at the Basel Life Science Week. Basel, Switzerland

http://www.basel-life-science-week.eu/2016/basel-life-science-week.html

20. May 23-25, 2017. Mixiii BioMed 2017 Conference, Tel Aviv, with a focus on aging and longevity R&D

https://www.iati.co.il/conference.php?ID=35

https://kenes-exhibitions.com/old/biomed2017/

https://www.israel21c.org/longevity-and-aging-focus-of-israeli-intl-biomed-confab/

21. August 7, 2017. Publication of the book “Longevity Promotion: Multidisciplinary Perspectives”

http://www.longevityhistory.com/

https://www.amazon.com/Longevity-Promotion-Multidisciplinary-Ilia-Stambler/dp/1974324265/

22. 2013-2017. The main sites for longevity promotion (created and co-created)

www.longevityisrael.org
www.longevityhistory.com

www.longevityforall.org
www.longevityalliance.org
www.healthspanpolicy.org
www.isoad.org

23. October 15, 2017. Conference “Pathways to Healthy Longevity” Bar Ilan University (organized)

https://www.longevityisrael.org/conference/

https://www.jpost.com/HEALTH-SCIENCE/Mechanism-discovered-to-extend-life-of-mice-by-tens-of-percentage-points-507753

https://www.facebook.com/VETEK.ISRLA/posts/1593609234034686

24. November 7, 2017. Launch of the Knesset Lobby “For Advancing the Preparedness of the Country for the Population Aging” and the Knesset Committee “For Creating the National Masterplan on Ageing” (at the same time)

https://oknesset.org/committees/2042.html

25. November-December 2017. Successful campaign for the inclusion of Aging into the WHO Work Program for 2019-2023

http://www.longevityforall.org/aging-is-now-included-into-the-who-work-program-thanks/

http://www.aginganddisease.org/EN/10.14336/AD.2017.1120

26. May 29, 2018. Launch of the Britain-Israel Research and Academic Exchange on Ageing – BIRAX Ageing.

http://www.longevityisrael.org/call-for-proposals-britain-israel-research-and-academic-exchange-partnership-on-ageing-birax-ageing/

https://www.britishcouncil.org.il/en/birax/projects/ageing

https://www.britishcouncil.org.il/sites/default/files/birax_ageing_call_for_proposals.pdf

https://www.britishcouncil.org.il/en/birax/call-for-proposals

27. May 8, 2018. Joining of forces for longevity activism in Israel, via the Vetek (Seniority) Association – the Movement for Longevity and Quality of Life

https://en.wikipedia.org/wiki/Rafi_Eitan

https://www.maariv.co.il/news/politics/Article-564969

https://www.longevityisrael.org/scientific-board/

https://www.longevityisrael.org/news/

http://www.longevityisrael.org/press/

28. July 9, 2018. Organizing a special session in Knesset at the Science and Technology Committee on “Enhancing Research, Development and Education for the Promotion of Healthy Longevity and Prevention of Aging-related Diseases”

https://www.longevityisrael.org/special-discussion-of-the-knesset-committee-on-science-and-technology-for-the-first-time-for-the-strengthening-of-research-and-development-for-improving-the-quality-of-life-and-longevity-and/

29. July 25, 2019. Thanks to the initiative of the Vetek (Seniority) Association – the Movement for Longevity and Quality of Life, the topic of “Research, Development and Education for Healthy Longevity and Prevention of Aging-related Diseases” is included in the summary report of the Knesset Committee for Creating the National Masterplan on Aging, as a strategic area for further discussion.

http://www.longevityisrael.org/research-development-and-education-for-healthy-longevity-is-included-in-israel-national-masterplan-on-aging/

https://main.knesset.gov.il/activity/committees/labor/Pages/CommitteeReports.aspx

https://oknesset.org/meetings/2/0/2072962.html

https://oknesset.org/meetings/2/0/2076804.html

30. July 12, 2018. Summary meeting of the Israeli Longevity Alliance (ISRLA) board

https://www.longevityisrael.org/

https://www.longevityisrael.org/news/

31. May 21, 2019. Raising awareness about healthy longevity research, development and education in cooperation with the “Disabled, Not Half a Person” association

https://www.lohetzi.co.il/%D7%90%D7%95%D7%93%D7%95%D7%AA%D7%99%D7%A0%D7%95/

32. 2012-2020. Promoting longevity activism online

http://www.longevityhistory.com/outreach-materials-for-longevity-promotion/

https://www.longevityforall.org/faq-of-the-ethics-of-lifespan-and-healthspan-extension/

http://www.longevityforall.org/frequently-asked-questions-on-the-ethics-of-lifespan-and-healthspan-extension/

https://hpluspedia.org/wiki/Ilia_Stambler

33. March 12, 2019. Publication of the analytical report “Longevity Industry in Israel”

https://www.aginganalytics.com/longevity-in-israel

https://www.longevityisrael.org/longevity-industry-in-israel-joint-report-by-vetek-association-and-aging-analytics-agency/

https://mindmaps.longevity.international/longevity-leaders-israel

34. March – July, 2019. Initiative to include R&D on aging into US-Israel cooperation. The bill passed the US House of Representatives, but did not go further.

https://www.congress.gov/bill/116th-congress/house-bill/1837/text

http://www.longevityisrael.org/us-israel-collaboration-on-aging-related-rd-is-planned/

https://www.longevityisrael.org/the-subject-of-aging-is-removed-from-the-us-israel-assistance-bill/

https://healthspanpolicy.org/israel-can-and-should-become-an-important-contributor-to-international-geroscience-research-development-applications-and-education

35. September 4-5, 2019. Co-organizing the conference International Perspectives in Geroscience, at Weizmann Institute of Science, with NIH sponsorship

http://www.weizmann.ac.il/conferences/IPG2019/international-perspectives-geroscience-israel

https://www.longevityisrael.org/geroscience-conference-program-weizmann-institute-september-4-5-2019/

https://nathanshockcenters.org/international-perspectives-on-geroscience-meetings

36. 2014-2022. Outreach coordinator and executive committee member of the International Society on Aging and Disease (ISOAD), including: Publication of the position paper “The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population” of the International Society on Aging and Disease (ISOAD). Since its publication in December 2014, until January 2022, this position paper had over 200 academic citations, appeared in 12 languages, was submitted to several governments. More position papers by the ISOAD were published, and in 2021 ISOAD obtained the special consultative status at the UN Economic and Social Council (ECOSOC).

http://www.longevityforall.org/the-critical-need-to-promote-research-of-aging-around-the-world/

http://www.aginganddisease.org/EN/10.14336/AD.2014.1210

https://scholar.google.com/scholar?oi=bibs&hl=en&cites=1393722017588130205,11094363600232984061

https://esango.un.org/civilsociety/consultativeStatusSummary.do?profileCode=649295

http://isoad.org/Data/List/Officers

http://isoad.org/Data/List/Chapters

http://www.aginganddisease.org/EN/10.14336/AD.2017.1120

http://www.aginganddisease.org/EN/10.14336/AD.2019.1230

37. 2012-2022. Research on the evaluation of aging health, utilizing information-theoretical measures. The Quantified Longevity Guide project

https://www.longevityisrael.org/quantified-longevity-guide/

https://ec.europa.eu/eip/ageing/commitments-tracker/a3/
quantified-longevity-guide-qlg_en

https://www.frontiersin.org/research-topics/14483/clinical-evaluation-criteria-for-aging-and-aging-related-multimorbidity

https://www.sciencedirect.com/science/article/pii/S0301008215300599?via%3Dihub

https://expertscape.com/au/information+theory/Stambler%2C+Ilia

https://expertscape.com/au/aging/Stambler%2C+I

38. 2020-2021. Promoting the amelioration of aging as a critical means to fight the epidemiological (e.g. COVID-19) crises

https://www.jpost.com/opinion/we-can-do-more-to-help-the-elderly-cope-with-the-covid-19-crisis-642408

http://www.aginganddisease.org/EN/10.14336/AD.2020.0629

http://www.aginganddisease.org/EN/10.14336/AD.2020.0228

http://www.aginganddisease.org/EN/10.14336/AD.2020.0603

https://www.linkedin.com/pulse/2020-showed-need-promote-aging-ameliorating-therapies-ilia-stambler/

https://www.longevityforall.org/we-call-for-open-anonymized-medical-data-oncovid-19-and-aging-related-risk-factors/

https://www.longevityforall.org/metchnikoff-day-may-15-online-conference-may-16/

39. 2012-2022. Promoting the recognition of aging as a treatable medical condition

http://www.singulariut.com/2012/07/601

https://web.archive.org/web/20120720024947/http://ieet.org/index.php/IEET/more/stambler201207171

http://www.aginganddisease.org/EN/10.14336/AD.2017.0130

https://link.springer.com/referenceworkentry/10.1007%2F978-3-319-69892-2_399-1

https://www.frontiersin.org/articles/10.3389/fgene.2021.764874/full

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00305-6/fulltext

40. 2021-2022. Continued promotion of healthy longevity research, development, education and application

http://www.longevityhistory.com/about-the-author/

Updates 2022, 2023, 2024,…. (as of January 20, 2025)

Continuing to keep this anniversary, 3 more years of longevity activism have passed, more work was done.

https://www.longevityforall.org/23-years-of-longevity-activism/

2022

In 2022, the activity mostly focused on writing academic and popular papers, and educational promotions on line at conferences and lectures.
https://www.longevityisrael.org/longevity-education-in-2022/

2023

The activities in 2023 mostly focused on developing the Vetek (Seniority) Association – the Movement for Longevity and Quality of Life in Israel, its conference (Longevity Nation, on March 26-27, 2023), online platform, collaborations, administration, policy outreach, public demonstration and campaigns, media coverage, scientific and popular scientific publications.
https://www.longevityisrael.org/vetek-association-yearly-report-2023/

2024

The activities in 2024 mostly focused on developing International Longevity Alliance (ILA), in particular encouraging the Longevity Month campaign in October and increasing the ILA membership and exposure.

https://www.longevityforall.org/ila-yearly-report-2024/

and developing the Vetek (Seniority) Association – the Movement for Longevity and Quality of Life in Israel, especially organizing the Longevity Nation conference in Bar-Ilan University on October 28-31 (end of the Longevity Month)

https://longevitynation.org/

https://www.longevityisrael.org/

In relation to activism (generally strengthening the involvement in the longevity field), also research and educational work was done (publications and conferences).

https://www.longevityhistory.com/about-the-author/

Hopefully, it will be possible to make or encourage additional contributions to our common goal of healthy longevity for all.

Hoping for a continuation of productive activism for the promotion of healthy longevity.
https://www.longevityforall.org/20-years-of-longevity-activism/

https://www.longevityforall.org/23-years-of-longevity-activism/

https://www.longevityhistory.com/about-the-author/

Advanced pathological ageing should be represented in the ICD, Lancet Healthy Longevity, January 2022

January 6, 2022Advocacy, Scienceilia2014

Happy and proud to see our correspondence article published in “Lancet Healthy Longevity”, entitled “Advanced pathological ageing should be represented in the ICD”

By Ilia Stambler, Aleksey Alekseev, Yuri Matveyev, and Daria Khaltourina

(free and open access)

https://doi.org/10.1016/S2666-7568(21)00305-6

And happy to join forces with another correspondence article, in the same issue of “Lancet Healthy Longevity”, with the same title, by Evelyne Bischof, Andrea B Maier, Kai-Fu Lee, Alex Zhavoronkov, and David Sinclair.

https://doi.org/10.1016/S2666-7568(21)00303-2

These articles appeared in response to a campaign raised by some gerontologists to remove the designation “Old age” from the new version of the International Classification of Diseases – ICD-11 (the code “Old Age” MG2A), as they claimed this designation would sound discriminatory against older people simply because of their age (“ageist”).

This campaign is exemplified by the article of Debanjan Banerjee et al. “Not a disease: a global call for action urging revision of the ICD-11 classification of old age” in “Lancet Healthy Longevity” to which we respond

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00201-4/fulltext

As well as others

https://www.paho.org/journal/en/articles/old-age-and-new-icd-11-position-latin-american-academy-medicine-older-persons

https://www.ageing.ox.ac.uk/blog/ICD-11-and-an-argument-about-old%20age%20

https://www1.folha.uol.com.br/folha-100-anos/2020/08/queremos-morrer-velhos-mas-nao-de-velhice.shtml

https://www.portaldoenvelhecimento.com.br/a-velhice-e-uma-doenca/

There was perceived the danger that, because of this campaign, this entire category code would be removed, and thus aging would no longer be recognized as a contributor to disease or a part of age-related pathogenesis, which would have detrimental outcomes for the research, development and therapy specifically designed to address and prevent aging-related ill health. Thus the removal of this code could in practice damage the health of older people that the campaign wished to protect from ageist labels.

So our articles were intended to defend the remaining of this code, in order to draw attention and resources for research, development and treatment specifically to address and improve aging-related ill health.

And indeed, due to the campaign, an ICD revision was introduced concerning this code (made public after our articles were accepted).

https://icd.who.int/dev11/l-m/en#/http://id.who.int/icd/entity/835503193

Yet the result turned out to be even better for the purposes of supporting healthy longevity R&D and treatment, than the earlier version. It would not remove the code entirely, but just rename the main term from “Old age” to “Ageing associated decline in intrinsic capacity”. Indeed, the term “old age” was rather scientifically ambiguous, while the new main term encourages practical projects to define, measure and improve the “intrinsic capacity” of older persons (which is currently not well defined or widely adopted). At the same time, all the code synonyms that would help address aging as a medical condition remained, including over 40 “index terms” altogether, such as ‘Ageing’, ‘Senescence’, ‘Senile state’, ‘Frailty’, and ‘Senile dysfunction’, that we also mention in our article and whose practical utilization we support.

https://icd.who.int/dev11/l-m/en#/http://id.who.int/icd/entity/835503193

At the same time it should be noted that the new revision (“Ageing associated decline in intrinsic capacity”) is set in motion, but the official released version of ICD-11(that came into effect on January 1, 2022) still mentions “Old age”.

https://icd.who.int/browse11/l-m/en#/http%3a%2f%2fid.who.int%2ficd%2fentity%2f835503193

https://icd.who.int/ct11/icd11_mms/en/release (search “ageing”)

But those semantic distinctions may not be crucial, as in either case, with the main stated significance of this code being the “general symptoms” of ageing, the attention would be drawn to addressing aging pathology and improving aging-related ill health, the need for which we also argue in our article. Notice additionally that neither version directly refers to aging as a “disease”, but refers to “general symptoms” (similar to the “general symptoms” of “cachexia”, fatigue”, “shock”, “sleep disturbance” etc. that are also in the ICD). This designation as “general symptoms” may help address aging as a medical condition generally. This is in addition to the “XT9T Ageing-related” ICD-11 code in the “Etiology” or “Causality” category.

https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/459275392

Thus the main message and fact remain:

AGING IS NOW IN THE ICD AND CAN BE OFFICIALLY ADDRESSED AS A MEDICAL CONDITION!!! And this can help address and improve aging health!

It should also be noted that mere semantics will not be effectual for the good or bad of aging health. In order to practically implement the ICD aging categories, it will be necessary to develop and implement evidence-based metrics and clinical evaluation criteria for aging, not just to predict the trajectory of aging health but also necessary to test the effects of geroprotective or healthspan improving interventions, as we also argue elsewhere.

https://www.frontiersin.org/articles/10.3389/fgene.2021.764874/full

http://www.aginganddisease.org/EN/10.14336/AD.2017.0130

Hopefully our joint work, with the other co-authors and partners, will further stimulate this discussion and research. It was a great honor to be a part of this stellar team!

(Just to note, the views expressed in this post are my personal views, following our article publication and the public introduction of the new main term “intrinsic capacity” after our article was accepted). These are not necessarily the views of the other co-authors and partners. For our joint views, please see the articles themselves. Thanks for your consideration! Ilia Stambler)

https://doi.org/10.1016/S2666-7568(21)00305-6

https://doi.org/10.1016/S2666-7568(21)00303-2

#aging #longevity #oldage #geroscience #ICD11 #medicalcondition

Cryonics according to Halakha

October 29, 2021Advocacy, Hebrew עבריתilia2014

קריוניקה בהלכה

מאת הרב אור שרגא

נשאלתי על ידי כמה אנשים מה דעת ההלכה היהודית כלפי שימור קריוני.

https://www.facebook.com/or.shraga.7/posts/10227243783786219

אומנם התחלתי לכתוב על קריוניקה אבל על הדרך כבר דנתי לכלל דיני קבורה ושאר עניינים.

[המסקנה שלי לגבי דין קבורה בכללי: שיש לבטל את צורת הקבורה הקיימת כיום שהיא בעייתית ולעבור לכתחילה לקבורת כוכים שהייתה נהוגה וכמו שבנו מעין זה בירושליים לאחרונה. ולגבי קריוניקה: אדם שיבקש לעשות כן זה כן תחשב לו כקבורה ויש לעשות כן]

1. כאן שאלה ששאל ד”ר איליה סטמבלר בנושא כבר בשנת 2012

מכון שלזינגר יחס ההלכה לקריוגניקה – מכון שלזינגר

https://www.medethics.org.il/

Download

2. הערך קריוניקה בויקפדיה העברית

https://he.m.wikipedia.org/

3. סרטון הדמיה לתהליך הקריוני ששמתי לו כתוביות בעברית

https://www.facebook.com/109521644831198/posts/115614970888532/

4. סיור פרטי שעשו לי בAlcor שבאריזונה ארה”ב אחד ממרכזי השימור הקריוני הקיימים

https://www.facebook.com/1407774229/posts/10226862904864484/

תוכן עניינים

קריוניקה בהלכה – אור שרגא

המושג קריוניקה, הדרכים השונות בהם טיפלו בגופת המת והשתלשלות הקבורה ביהדות (2-7)

מקור דין קבורה בסוגיא בסנהדרין ביאור הסוגיא ובטעם קבורה ובביאור המושגים בזיונא וכפרה (7-12)

במה עובר המלין את מתו (12-13)

הכרעת הגמ’ באיבעיא האם הוי משום בזיונא או משום כפרה (13)

האם קבורה מדאורייתא או מדרבנן (13-19)

ממתי עובר על בל תלין (20-21)

האומר שלא יקברו אותו האם שומעים לו (20)

דין קבורה בארון (21-26)

דין ניוול המת (26-29)

דין חניטה (29-31)

דין שריפת המת (32-33)

דין קבורת אבר וקבורת אפר ופחות מכזית מן המת (33)

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Cryonics according to Halakha

Halakhic attitude to cryonics

Longevity Month – October 2021

October 2, 2021Advocacyilia2014

The United Nations General Assembly voted to establish October 1st as the ‘International Day of Older Persons’ as recorded in Resolution 45/106. The holiday was observed for the first time on October 1st, 1991.

Following this tradition, longevity research activists from around the world call this day and the month of October; International Longevity Day and International Longevity Month.

Events focused on supporting biomedical research to further understand the biology of aging and extend healthy human lifespan, take place internationally throughout the entire month of October.

Since 2013 hundreds of events have been organized and we hope this tradition will continue and will keep strengthening the longevity advocacy community.

Also in 2021, events have been organized around the world. Though initiated from various specific countries, they are mostly online and thus international, including:

Nigeria

https://www.facebook.com/agbolade.omowole/posts/10226818543560617

Bulgaria

https://www.facebook.com/events/900360290915864?ref=newsfeed

https://www.facebook.com/groups/280389975798657/posts/1209101016260877/

Brazil

https://www.facebook.com/portalterceiraidade/videos/570001527611700

Malaysia

https://www.facebook.com/wteforum/videos/1303709303394949

https://youtu.be/TgwDpW8mFQk?t=297

https://www.raadfest.com/

Spain

https://www.transvisionmadrid.com/

India

On the occasion of Longevity Day, 1st October, India Future Society announced an open competition for individuals/organizations to submit applications on the theme of Indo-Futurism.

https://indiafuturesociety.org/call-for-entries-on-indo-futurism/

If you organize an event, create a publication, an awareness action, or make any other effort to promote International Longevity Day/Month, we would love to learn about it! You can let us know by emailing us at ila-lead@googlegroups.com

Chronographic Aging Project

August 18, 2021Scienceilia2014

By Alexey Olovnikov, PhD

[Published with permission of Dr. Olovnikov in search of support for his work and cooperation]

The essence of the chronographic aging theory, the possibility of its verification and consequences

The chronographic theory of aging (Olovnikov A.M. Chronographic theory of development, aging, and origin of cancer: Role of chronomeres and printomeres. Curr Aging Sci. 2015; 8 (1): 76-88) is based on the assumption of a consistent loss by brain’s neurons of their special extra-chromosomal DNA amplificates. They are copies of some regulatory sites of chromosomal DNA. Chromosomal originals of these copies remain virtually intact until the end of the organism’s life. Gradually losing these amplificates from neurons, a body, owing to this process, evaluates the course of endogenous time throughout life. Amplificates in neurons of a brain are designated as chronomeres. Similar amplificates are also present in other, non-neuronal cells, where they are referred to as printomeres. All these amplificates are the double-stranded DNA molecules. They are relatively small perichromosomal copies of their chromosomal originals. The length of chronomeres may be from a few hundred to thousands of nucleotides. Different chronomeres have distinct sequences depending on the specificity of those neurons in which they are located. Each chronomere is aligned “side by side” with its chromosomal original, that is next to it, though extrachromosomally. In other words, each chronomere is represented by an independent separate DNA molecule. Chronomere is fixed on a body of its chromosome like a fish-sticking on shark – in the sense that chronomere uses the chromosome as a physical support. Retention of chronomere on the support is assisted with auxiliary heterochromatin’s proteins. The nucleotide sequence of the chronomere and its chromosomal original (the corresponding regulatory sequence of chromosomal DNA ) are identical. Therefore, chronomere sequences during the routine DNA sequencing remain unnoticed.

Chronomeres and printomeres are involved in maintaince of cellular differentiation, i.e. these perichromosomal organelles participate in the control of cell specificity. But in the brain’s neurons, chronomeres are responsible also for an another specific function: they are part of the life-long clock of a body. In neurons that differ in specificity, chronomeres respectively have distinct DNA sequences. Corresponding neurons, when they sequentially lose their chronomeres, are able to inform the body about its current physiological age: in this manner the neurons do change the properties of innervated body’s targets, i.e. body’s corresponding systems, organs, tissues and cells. That is why the numerous physiological and even anatomical characteristics gradually change in any person over time. Due to the loss of chronomeres by neurons, the body “knows” when, for example, it is the time to implement the puberty, when it is time for menopause or andropause, etc. Chronomere-related lifelong clock, or neuronal chronograph, performs its “ticking” already in the embryo, thus participating in the formation and then in the physiological maturation of the organism. But continuing to “tick” after maturation of his host, chronograph is eventually leading a host to the grave. The smaller the number of chronomeres left in the brain of an old person, the less, ceteris paribus, time is left to live for this human being.

Potential therapeutic uses of chronomeres: In the future, when it will be possible to regenerate chronomeres in an old brain (using as templates their chromosomal originals, which unlike chronomeres do not disappear from neurons), the doctors will be able to literally “twist off the clock back”, i.e. to directly rejuvenate the person. Another alternative is potentially not ruled out also – by slowing the losses of chronomeres it will be possible to get virtually a complete control over the pace of aging. To get such possibilities, it is necessary to perform enough hard work. The first crucial step is to find these amplificates. Only then the search for pharmacological and other means, which allow to control the process of aging, may become possible.

Linear DNA of chronomere has free ends, they are designated as the acromeres, to distinguish them from the telomeres that protect the free ends of the chromosomal DNA. Like telomeres, acromeres should protect its linear chronomeric DNA at its ends from exonucleases. By their nucleotide sequences, acromeres with high probability should have the vertebrate-like telomere repeats. In humans, the acromeres also may have TTAGGG repeats, but the number of such repeates in each acromere are probably much less compared with the long telomeres in the same neurons.

What should be done to identify chronomeres?

One can treat the samples of neuronal nuclear DNA with terminal transferase to add, for example, poly-T to all 3’ ends of DNA. Since the two DNA strands in a linear DNA molecule are antiparallel, the both poly-T tails in any sought-for amplificate (in a chronomere, as well as in a printomere) will be in an inverted orientation in regard to each other. The identification of such structures in the samples of neuronal chromosomes (using all proper controls to exclude occasional DNA breaks) will show the presence and even the locations of the sought-for chronomeres on the surface of chromosomal DNA in neurons.

Next steps – sequencing of identified chronomeres and preparing of catalogues of chronomeres for humans and laboratory animals. Following this, it will be possible to look for ways to regenerate chronomeres – restoring the aged neurons in vitro and then in the aged brains of animals. Also it will be possible to use some viral vectors armed with chronomeric sequences as an alternative way of neuronal rejuvenation.

A proved absence of the predicted perichromosomal amplificates in neurons would be a complete and unconditional refutation of the chronographic theory of aging. On the contrary, detection of chronomeres will be a pivotal event that will open the straight path to a future victory over numerous age-related pathologies and aging itself.

The key predictions of my former theory concerning cell aging, namely telomere theory, were: i) shortening of telomeres in dividing cells, ii) the existence of a special variant of DNA polymerase (a telomerase in current terminology), which should compensate telomere shortening, and iii) the prediction that this enzyme should be found in cancer cells and in sex cells. All these predictions of mine were confirmed – a quarter of a century later after their publication. The founder of Geron Corporation, Dr. M. West, has noted that this Corporation was organized taking into account the ideas of my telomere theory. The material on this subject can be found, for example, on these websites: http://www.michaelwest.org/Telomeres-as-the-Clock-of-Aging-and-Immortalization.htm ; https://web.archive.org/web/20161026194847/http://www.evidencebasedcryonics.org/2008/10/12/biotimes-quest-to-defeat-aging/ “Dr. West became so convinced of Olovnikov’s theory that he formed a company called Geron to investigate it further. As reported by Life Extension Magazine: “Forty million dollars later,” West recalls, “the gamble paid off.” West’s group had in fact produced Olovnikov’s mysterious enzyme…”

The aging of a body, though it is composed of cells, cannot be explained, however, only through the senescence of individual cells. Chronographic theory refers now to the higher levels of regulation, explaining both cellular aging and, more importantly, the organismal aging. It is not difficult to foresee that a new direction suggested by my chronographic theory of aging also will attract in the future the worldwide attention of scientific institutions and companies. Is it necessary to waste again another decades?

Alexey M. Olovnikov,

Moscow, olovnikov@gmail.com